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| [[Image:1cnt.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1cnt| PDB=1cnt | SCENE= }} | | {{STRUCTURE_1cnt| PDB=1cnt | SCENE= }} |
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| '''CILIARY NEUROTROPHIC FACTOR'''
| | ===CILIARY NEUROTROPHIC FACTOR=== |
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| ==Overview==
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| Ciliary neurotrophic factor (CNTF) promotes the survival and differentiation of developing motor neurons and is a potential therapeutic for treating neurodegeneration and nerve injury. The crystal structure of human CNTF has been determined at 2.4 A resolution using multi-wavelength anomalous diffraction (MAD) phasing from a single Yb3+ ions. The structure reveals that CNTF is dimeric, with a novel anti-parallel arrangement of the subunits, not previously observed for other cytokines. Each subunit adopts a double crossover four-helix bundle fold, in which two helices contribute to the dimer interface, whilst two different helices show pronounced kinks. Analysis of the electrostatic surface of CNTF identified residues within these kinked helices that may contact the CNTF receptor-alpha. Solution experiments show that CNTF dimerizes at concentrations > 40 microM. Such dimers are likely to be relevant to the storage of CNTF in the peripheral nerve given the high concentrations present in this tissue. However, it is unlikely that they play a role in engaging the three distinct receptor subunits that comprise the CNTF receptor, given the low concentration of extracellular CNTF and its high potency.
| | The line below this paragraph, {{ABSTRACT_PUBMED_7796798}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 7796798 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_7796798}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Growth factor]] | | [[Category: Growth factor]] |
| [[Category: Neurotrophic factor]] | | [[Category: Neurotrophic factor]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:55:50 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:00:00 2008'' |
