6kyr: Difference between revisions
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==Crystal structure of DCLK1 mutant (P675L) Autoinhibited Kinase Domain== | ==Crystal structure of DCLK1 mutant (P675L) Autoinhibited Kinase Domain== | ||
<StructureSection load='6kyr' size='340' side='right'caption='[[6kyr]]' scene=''> | <StructureSection load='6kyr' size='340' side='right'caption='[[6kyr]], [[Resolution|resolution]] 2.21Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KYR OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6kyr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KYR FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DCLK1, DCAMKL1, DCDC3A, KIAA0369 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kyr OCA], [https://pdbe.org/6kyr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kyr RCSB], [https://www.ebi.ac.uk/pdbsum/6kyr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kyr ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/DCLK1_HUMAN DCLK1_HUMAN]] Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. | |||
==See Also== | |||
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chen Q]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Yu Y]] | [[Category: Chen, Q]] | ||
[[Category: Yu, Y]] | |||
[[Category: Autoinhibition]] | |||
[[Category: Kinase]] | |||
[[Category: Signaling protein]] | |||
Revision as of 09:58, 8 December 2021
Crystal structure of DCLK1 mutant (P675L) Autoinhibited Kinase Domain
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