3il8: Difference between revisions

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<StructureSection load='3il8' size='340' side='right'caption='[[3il8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3il8' size='340' side='right'caption='[[3il8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3il8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3IL8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3il8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IL8 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il8 OCA], [http://pdbe.org/3il8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3il8 RCSB], [http://www.ebi.ac.uk/pdbsum/3il8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3il8 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il8 OCA], [https://pdbe.org/3il8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3il8 RCSB], [https://www.ebi.ac.uk/pdbsum/3il8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3il8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IL8_HUMAN IL8_HUMAN]] IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.<ref>PMID:2145175</ref> <ref>PMID:2212672</ref> <ref>PMID:11978786</ref>
[https://www.uniprot.org/uniprot/IL8_HUMAN IL8_HUMAN] IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.<ref>PMID:2145175</ref> <ref>PMID:2212672</ref> <ref>PMID:11978786</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Appella, E]]
[[Category: Appella E]]
[[Category: Baldwin, E T]]
[[Category: Baldwin ET]]
[[Category: Charles, R St]]
[[Category: Clore GM]]
[[Category: Clore, G M]]
[[Category: Edwards BFP]]
[[Category: Edwards, B F.P]]
[[Category: Gronenborn AM]]
[[Category: Gronenborn, A M]]
[[Category: Matsushima K]]
[[Category: Matsushima, K]]
[[Category: St Charles R]]
[[Category: Weber, I T]]
[[Category: Weber IT]]
[[Category: Wlodawer, A]]
[[Category: Wlodawer A]]
[[Category: Xuan, J C]]
[[Category: Xuan J-C]]
[[Category: Yamada, M]]
[[Category: Yamada M]]
[[Category: Cytokine]]