1cok: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1cok.gif|left|200px]]
{{Seed}}
[[Image:1cok.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1cok|  PDB=1cok  |  SCENE=  }}  
{{STRUCTURE_1cok|  PDB=1cok  |  SCENE=  }}  


'''STRUCTURE OF THE C-TERMINAL DOMAIN OF P73'''
===STRUCTURE OF THE C-TERMINAL DOMAIN OF P73===




==Overview==
<!--
p73 and p63 are two recently cloned genes with homology to the tumor suppressor p53, whose protein product is a key transcriptional regulator of genes involved in cell cycle arrest and apoptosis. While all three proteins share conserved transcriptional activation, DNA-binding and oligomerization domains, p73 and p63 have an additional conserved C-terminal region. We have determined the three-dimensional solution structure of this conserved C-terminal domain of human p73. The structure reveals a small five-helix bundle with striking similarity to the SAM (sterile alpha motif) domains of two ephrin receptor tyrosine kinases. The SAM domain is a putative protein-protein interaction domain found in a variety of cytoplasmic signaling proteins and has been shown to form both homo- and hetero-oligomers. However, the SAM-like C-terminal domains of p73 and p63 are monomeric and do not interact with one another, suggesting that this domain may interact with additional, as yet uncharacterized proteins in a signaling and/or regulatory role.
The line below this paragraph, {{ABSTRACT_PUBMED_10449409}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10449409 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_10449409}}


==About this Structure==
==About this Structure==
1COK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COK OCA].  
1COK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COK OCA].  


==Reference==
==Reference==
Line 27: Line 31:
[[Category: Gene regulation]]
[[Category: Gene regulation]]
[[Category: P73 sam-like domain]]
[[Category: P73 sam-like domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:57:03 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:01:30 2008''

Revision as of 18:01, 30 June 2008

File:1cok.png

Template:STRUCTURE 1cok

STRUCTURE OF THE C-TERMINAL DOMAIN OF P73

Template:ABSTRACT PUBMED 10449409

About this Structure

1COK is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain., Chi SW, Ayed A, Arrowsmith CH, EMBO J. 1999 Aug 16;18(16):4438-45. PMID:10449409

Page seeded by OCA on Mon Jun 30 21:01:30 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1cok&oldid=583577"