5uj8: Difference between revisions

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<StructureSection load='5uj8' size='340' side='right'caption='[[5uj8]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
<StructureSection load='5uj8' size='340' side='right'caption='[[5uj8]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5uj8]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UJ8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5UJ8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5uj8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UJ8 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5uj7|5uj7]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 6&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ORC3, LATHEO, ORC3L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ORC2, ORC2L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uj8 OCA], [https://pdbe.org/5uj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uj8 RCSB], [https://www.ebi.ac.uk/pdbsum/5uj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uj8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5uj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uj8 OCA], [http://pdbe.org/5uj8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uj8 RCSB], [http://www.ebi.ac.uk/pdbsum/5uj8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uj8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ORC3_HUMAN ORC3_HUMAN]] Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.<ref>PMID:22427655</ref> [[http://www.uniprot.org/uniprot/ORC2_HUMAN ORC2_HUMAN]] Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.<ref>PMID:22427655</ref> <ref>PMID:22935713</ref> 
[https://www.uniprot.org/uniprot/ORC3_HUMAN ORC3_HUMAN] Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.<ref>PMID:22427655</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Elkayam, E]]
[[Category: Elkayam E]]
[[Category: Joshua-Tor, L]]
[[Category: Joshua-Tor L]]
[[Category: On, K F]]
[[Category: On KF]]
[[Category: Tocilj, A]]
[[Category: Tocilj A]]
[[Category: Atpase]]
[[Category: Hydrolase]]
[[Category: Orc]]
[[Category: Replication]]
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