7a6u: Difference between revisions
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==Cryo-EM structure of the cytoplasmic domain of human TRPC6== | ==Cryo-EM structure of the cytoplasmic domain of human TRPC6== | ||
<StructureSection load='7a6u' size='340' side='right'caption='[[7a6u]]' scene=''> | <StructureSection load='7a6u' size='340' side='right'caption='[[7a6u]], [[Resolution|resolution]] 3.62Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A6U OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[7a6u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A6U FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRPC6, TRP6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a6u OCA], [https://pdbe.org/7a6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a6u RCSB], [https://www.ebi.ac.uk/pdbsum/7a6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a6u ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[[https://www.uniprot.org/uniprot/TRPC6_HUMAN TRPC6_HUMAN]] Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/TRPC6_HUMAN TRPC6_HUMAN]] Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion.<ref>PMID:19936226</ref> <ref>PMID:23291369</ref> <ref>PMID:26892346</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra C]] | [[Category: Bountra, C]] | ||
[[Category: Burgess-Brown | [[Category: Burgess-Brown, N A]] | ||
[[Category: Carpenter | [[Category: Carpenter, E P]] | ||
[[Category: Chalk R]] | [[Category: Chalk, R]] | ||
[[Category: Edwards | [[Category: Edwards, A M]] | ||
[[Category: Grieben M]] | [[Category: Grieben, M]] | ||
[[Category: Marsden | [[Category: Marsden, B D]] | ||
[[Category: Mukhopadhyay | [[Category: Mukhopadhyay, S M.M]] | ||
[[Category: Pike | [[Category: Pike, A C.W]] | ||
[[Category: Wang D]] | [[Category: Structural genomic]] | ||
[[Category: Wang, D]] | |||
[[Category: Ion transport protein transient receptor ion channel ii]] | |||
[[Category: Membrane protein]] | |||
[[Category: Sgc]] | |||
