1cq0: Difference between revisions

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[[Image:1cq0.jpg|left|200px]]
{{Seed}}
[[Image:1cq0.png|left|200px]]


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{{STRUCTURE_1cq0|  PDB=1cq0  |  SCENE=  }}  
{{STRUCTURE_1cq0|  PDB=1cq0  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF A HUMAN HYPOCRETIN-2/OREXIN-B'SOLUTION STRUCTURE OF A HUMAN HYPOCRETIN-2/OREXIN-B ''''
===SOLUTION STRUCTURE OF A HUMAN HYPOCRETIN-2/OREXIN-B'SOLUTION STRUCTURE OF A HUMAN HYPOCRETIN-2/OREXIN-B '===




==Overview==
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Orexin-A and orexin-B (also called hypocretin-1 and hypocretin-2, respectively) are novel hypothalamic neuropeptides encoded by a single mRNA transcript; they stimulate food intake. We have determined the three-dimensional solution structure of human hypocretin-2/orexin-B using two-dimensional 1H-NMR data and dynamical simulated annealing calculations. On the basis of NOEs, 3JHNalpha coupling constants and hydrogen-deuterium exchange rates together with chemical shift indices, human hypocretin-2/orexin-B was deduced to consist of two alpha-helices connected with a short linker in both H2O and 30% trifluoroethanol solutions. The helical axis of helix I is oriented about 60-80 degrees relative to helix II. Hybrid distance geometry and simulated-annealing protocols were used to generate an ensemble of 30 structures with no constraint violations greater than 0.03 nm for distances and 3 degrees for angles. In addition, human hypocretin-2/orexin-B shares a similar secondary-structural motif with human neuropeptide Y. This result can form the basis for further study on ligand-receptor recognition of human orexin receptors.
The line below this paragraph, {{ABSTRACT_PUBMED_10583376}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10583376 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10583376}}


==About this Structure==
==About this Structure==
1CQ0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CQ0 OCA].  
1CQ0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CQ0 OCA].  


==Reference==
==Reference==
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[[Category: Obesity]]
[[Category: Obesity]]
[[Category: Solution structure]]
[[Category: Solution structure]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:59:27 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:05:39 2008''

Revision as of 18:05, 30 June 2008

File:1cq0.png

Template:STRUCTURE 1cq0

SOLUTION STRUCTURE OF A HUMAN HYPOCRETIN-2/OREXIN-B'SOLUTION STRUCTURE OF A HUMAN HYPOCRETIN-2/OREXIN-B '

Template:ABSTRACT PUBMED 10583376

About this Structure

1CQ0 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B., Lee JH, Bang E, Chae KJ, Kim JY, Lee DW, Lee W, Eur J Biochem. 1999 Dec;266(3):831-9. PMID:10583376

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