5wdi: Difference between revisions

<table><tr><td colspan='2'>[[5wdi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WDI FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wdi OCA], [https://pdbe.org/5wdi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wdi RCSB], [https://www.ebi.ac.uk/pdbsum/5wdi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wdi ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/UBS3A_HUMAN UBS3A_HUMAN] Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.<ref>PMID:15159412</ref> <ref>PMID:17382318</ref> <ref>PMID:18189269</ref>  

[[Category: Carpino N]]

[[Category: French JB]]

[[Category: Kaur N]]

[[Category: Weinheimer AW]]

[[Category: Yin Y]]

[[Category: Zhou W]]