User:Jordan Scott/Sandbox RNA polII: Difference between revisions
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4.<scene name='86/862225/Tfiie/6'>TFIEE</scene> is required to begin transcription even though RNAP II is bound to DNA before TFIIE binds. Once bound it recruits TFIIH. TfIIE is an α2β2 heterotetramer of 35 and 56 kDA. <ref name="txn"/> | 4.<scene name='86/862225/Tfiie/6'>TFIEE</scene> is required to begin transcription even though RNAP II is bound to DNA before TFIIE binds. Once bound it recruits TFIIH. TfIIE is an α2β2 heterotetramer of 35 and 56 kDA. <ref name="txn"/> | ||
5.<scene name='86/862225/Tfiih/'>TFIIH</scene> supports catalytic activity such as DNA ATPase, DNA helicase, and a kinase that phosphorylates the CTD of RPB1.<ref name="txn"/>(F) Some of its subunits are also components of DNA repair machinery. It is the last TF to bind and completes the <scene name='82/824648/Pic/3'>PIC</scene>. | 5.<scene name='86/862225/Tfiih/3'>TFIIH</scene> supports catalytic activity such as DNA ATPase, DNA helicase, and a kinase that phosphorylates the CTD of RPB1.<ref name="txn"/>(F) Some of its subunits are also components of DNA repair machinery. It is the last TF to bind and completes the <scene name='82/824648/Pic/3'>PIC</scene>. | ||
6.<scene name='86/862225/Tfiia/3'>TFIAA</scene> is a co-activator that helps regulate PIC assembly. It was initially thought to be essential for activity. It binds to and stabilizes the early complexes. It also neutralizes transcription repressors. The mechanism is unknown but it is thought to either increase TBP affinity for DNA or displace repressors. TFIIA binds to the N-terminal of TBP. It lies upstream, of TATA where it can interact with promoter and enhancer elements.<ref name="txn"/> | 6.<scene name='86/862225/Tfiia/3'>TFIAA</scene> is a co-activator that helps regulate PIC assembly. It was initially thought to be essential for activity. It binds to and stabilizes the early complexes. It also neutralizes transcription repressors. The mechanism is unknown but it is thought to either increase TBP affinity for DNA or displace repressors. TFIIA binds to the N-terminal of TBP. It lies upstream, of TATA where it can interact with promoter and enhancer elements.<ref name="txn"/> | ||
