1cqz: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
Line 1: Line 1:
[[Image:1cqz.jpg|left|200px]]
{{Seed}}
[[Image:1cqz.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1cqz|  PDB=1cqz  |  SCENE=  }}  
{{STRUCTURE_1cqz|  PDB=1cqz  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE.'''
===CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE.===




==Overview==
<!--
The crystal structure of recombinant murine liver cytosolic epoxide hydrolase (EC 3.3.2.3) has been determined at 2.8-A resolution. The binding of a nanomolar affinity inhibitor confirms the active site location in the C-terminal domain; this domain is similar to that of haloalkane dehalogenase and shares the alpha/beta hydrolase fold. A structure-based mechanism is proposed that illuminates the unique chemical strategy for the activation of endogenous and man-made epoxide substrates for hydrolysis and detoxification. Surprisingly, a vestigial active site is found in the N-terminal domain similar to that of another enzyme of halocarbon metabolism, haloacid dehalogenase. Although the vestigial active site does not participate in epoxide hydrolysis, the vestigial domain plays a critical structural role by stabilizing the dimer in a distinctive domain-swapped architecture. Given the genetic and structural relationships among these enzymes of xenobiotic metabolism, a structure-based evolutionary sequence is postulated.
The line below this paragraph, {{ABSTRACT_PUBMED_10485878}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10485878 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_10485878}}


==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Domain-swapping]]
[[Category: Domain-swapping]]
[[Category: Homodimer]]
[[Category: Homodimer]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:01:28 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:11:00 2008''

Revision as of 18:11, 30 June 2008

File:1cqz.png

Template:STRUCTURE 1cqz

CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE.

Template:ABSTRACT PUBMED 10485878

About this Structure

1CQZ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase., Argiriadi MA, Morisseau C, Hammock BD, Christianson DW, Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10637-42. PMID:10485878

Page seeded by OCA on Mon Jun 30 21:11:00 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1cqz&oldid=583916"