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==1H NMR structure determination of Viscotoxin C1==
==1H NMR structure determination of Viscotoxin C1==
<StructureSection load='1orl' size='340' side='right'caption='[[1orl]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='1orl' size='340' side='right'caption='[[1orl]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1orl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ORL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1ORL FirstGlance]. <br>
<table><tr><td colspan='2'>[[1orl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ORL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ORL FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ed0|1ed0]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1orl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1orl OCA], [http://pdbe.org/1orl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1orl RCSB], [http://www.ebi.ac.uk/pdbsum/1orl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1orl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1orl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1orl OCA], [https://pdbe.org/1orl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1orl RCSB], [https://www.ebi.ac.uk/pdbsum/1orl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1orl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/THNB_VISAL THNB_VISAL]] Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. Their precise function is not known.[REFERENCE:3]  
[https://www.uniprot.org/uniprot/THNC_VISAL THNC_VISAL]  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1orl ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1orl ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The high resolution three-dimensional structure of the newly discovered plant viscotoxin C1, from the Asiatic Viscum album ssp. Coloratum ohwi, has been determined in solution by (1)H NMR spectroscopy at pH 3.6 and 285 K. The viscotoxin C1-fold, consisting of a helix-turn-helix motif and a short stretch of an antiparralel beta-sheet is very similar to that found for the highly similar viscotoxins A2 and A3 and for other related thionins. Different functional properties of members of the thionin family are discussed here in light of the structural and electrostatic properties. Among the very homologous family of alpha- and beta-thionins, known for their antimicrobial activity, the viscotoxin subfamily differs from the other members because of its high toxicity against tumoral cells. Key residues for the modulation of viscotoxin cytotoxicity have been identified on the basis of sequence and structural alignment.
NMR solution structure of viscotoxin C1 from Viscum album species Coloratum ohwi: toward a structure-function analysis of viscotoxins.,Romagnoli S, Fogolari F, Catalano M, Zetta L, Schaller G, Urech K, Giannattasio M, Ragona L, Molinari H Biochemistry. 2003 Nov 4;42(43):12503-10. PMID:14580196<ref>PMID:14580196</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1orl" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Viscum album]]
[[Category: Viscum album]]
[[Category: Catalano, M]]
[[Category: Catalano M]]
[[Category: Fogolari, F]]
[[Category: Fogolari F]]
[[Category: Giannattasio, M]]
[[Category: Giannattasio M]]
[[Category: Molinari, H]]
[[Category: Molinari H]]
[[Category: Ragona, L]]
[[Category: Ragona L]]
[[Category: Romagnoli, S]]
[[Category: Romagnoli S]]
[[Category: Urech, K]]
[[Category: Urech K]]
[[Category: Beta-sheet]]
[[Category: Concentric motif of disulphide bridge]]
[[Category: Helix-turn-helix]]
[[Category: Toxin]]

Revision as of 05:50, 17 April 2024

1H NMR structure determination of Viscotoxin C1

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