1csg: Difference between revisions

Line 1:

[[Image:1csg.~~gif~~|left|200px]]

[[Image:1csg.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR~~'''~~

===THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR===

~~==Overview==~~

<!--

The ~~crystal structure of recombinant human granulocyte-macrophage colony-stimulating factor~~ (~~rhGM-CSF) has been determined~~ at 2.~~8 A resolution using multiple isomorphous replacement techniques~~. ~~There are two molecules in the crystallographic asymmetric unit~~, which are related by an approximate non-crystallographic 2-fold axis. The overall structure is highly compact and globular with a predominantly hydrophobic core. The main structural feature of rhGM-CSF is ~~a four alpha-helix bundle, which represents approximately 42% of~~ the ~~structure~~. ~~The helices are arranged in a left~~-~~handed antiparallel bundle with two overhand connections. Within the connections is a two~~-stranded antiparallel beta-sheet. The tertiary structure of rhGM-CSF has a topology similar to that of porcine growth factor and interferon-beta. Most of the proposed critical regions for receptor binding are located on a continuous surface at one end of the molecule that includes the C terminus.

The line below this paragraph, {{ABSTRACT_PUBMED_1569568}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 1569568 is the PubMed ID number.

-->

==About this Structure==

Line 26:

Line 30:

[[Category: Walter, M R.]]

[[Category: Cytokine]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 13~~:04:07 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:16:57 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1csg.gif|left|200px]]
+{{Seed}}
+[[Image:1csg.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1csg|  PDB=1csg  |  SCENE=  }}
-'''THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR'''
+===THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR===
-==Overview==
+<!--
-The crystal structure of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) has been determined at 2.8 A resolution using multiple isomorphous replacement techniques. There are two molecules in the crystallographic asymmetric unit, which are related by an approximate non-crystallographic 2-fold axis. The overall structure is highly compact and globular with a predominantly hydrophobic core. The main structural feature of rhGM-CSF is a four alpha-helix bundle, which represents approximately 42% of the structure. The helices are arranged in a left-handed antiparallel bundle with two overhand connections. Within the connections is a two-stranded antiparallel beta-sheet. The tertiary structure of rhGM-CSF has a topology similar to that of porcine growth factor and interferon-beta. Most of the proposed critical regions for receptor binding are located on a continuous surface at one end of the molecule that includes the C terminus.
+The line below this paragraph, {{ABSTRACT_PUBMED_1569568}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 1569568 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_1569568}}
 ==About this Structure==
@@ Line 26: / Line 30: @@
 [[Category: Walter, M R.]]
 [[Category: Cytokine]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:04:07 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:16:57 2008''