1cto: Difference between revisions

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[[Image:1cto.gif|left|200px]]
{{Seed}}
[[Image:1cto.png|left|200px]]


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{{STRUCTURE_1cto|  PDB=1cto  |  SCENE=  }}  
{{STRUCTURE_1cto|  PDB=1cto  |  SCENE=  }}  


'''NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, MINIMIZED AVERAGE STRUCTURE'''
===NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, MINIMIZED AVERAGE STRUCTURE===




==Overview==
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We have determined the NMR structure of a ligand-binding domain of the granulocyte colony-stimulating factor (G-CSF) receptor, containing the highly conserved WSxWS motif. The domain consists of seven beta-strands with the fibronectin type III-like topology seen in several cytokine receptors. Comparisons between the spectra of the 15N-labelled domain with and without G-CSF indicate that the major ligand-recognition site is on the FG loop just upstream of the WSxWS sequence, and not on the BC loop which is mainly used in the growth hormone system. The WSxWS residues are suggested to contribute to ligand-recognition and to the protein architecture of the G-CSF receptor.
The line below this paragraph, {{ABSTRACT_PUBMED_9187659}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_9187659}}


==About this Structure==
==About this Structure==
1CTO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA].  
1CTO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA].  


==Reference==
==Reference==
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[[Category: Binding protein]]
[[Category: Binding protein]]
[[Category: Cytokine receptor]]
[[Category: Cytokine receptor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:05:59 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:21:01 2008''

Revision as of 18:21, 30 June 2008

File:1cto.png

Template:STRUCTURE 1cto

NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 9187659

About this Structure

1CTO is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand., Yamasaki K, Naito S, Anaguchi H, Ohkubo T, Ota Y, Nat Struct Biol. 1997 Jun;4(6):498-504. PMID:9187659

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