5xgr: Difference between revisions

<table><tr><td colspan='2'>[[5xgr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Bchk5 Bchk5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XGR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XGR FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xgr OCA], [http://pdbe.org/5xgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xgr RCSB], [http://www.ebi.ac.uk/pdbsum/5xgr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xgr ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/SPIKE_BCHK5 SPIKE_BCHK5]] S1 region attaches the virion to the cell membrane by interacting with cell receptors, initiating the infection.  S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity).  

[[Category: Gao, G F]]

[[Category: Qi, J]]

[[Category: Qihui, W]]

[[Category: Shi, Y]]

[[Category: Song, H]]

[[Category: Xue, H]]

[[Category: Viral protein]]