1tkx: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: left|200px<br /> <applet load="1tkx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tkx, resolution 2.85Å" /> '''CRYSTAL STRUCTURE O... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1tkx.gif|left|200px]]<br /> | [[Image:1tkx.gif|left|200px]]<br /><applet load="1tkx" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1tkx" size=" | |||
caption="1tkx, resolution 2.85Å" /> | caption="1tkx, resolution 2.85Å" /> | ||
'''CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745'''<br /> | '''CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745'''<br /> | ||
==Overview== | ==Overview== | ||
HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) are part of | HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) are part of the combination therapy currently used to treat HIV infection. The features of a new NNRTI drug for HIV treatment must include selective potent activity against both wild-type virus as well as against mutant virus that have been selected by use of current antiretroviral treatment regimens. Based on analogy with known HIV-1 NNRTI inhibitors and modeling studies utilizing the X-ray crystal structure of inhibitors bound in the HIV-1 RT, a series of substituted 2-quinolones was synthesized and evaluated as HIV-1 inhibitors. | ||
==About this Structure== | ==About this Structure== | ||
1TKX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with GWB as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http:// | 1TKX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=GWB:'>GWB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TKX OCA]. | ||
==Reference== | ==Reference== | ||
| Line 15: | Line 14: | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: RNA-directed DNA polymerase]] | [[Category: RNA-directed DNA polymerase]] | ||
[[Category: Hopkins, A | [[Category: Hopkins, A L.]] | ||
[[Category: Ren, J.]] | [[Category: Ren, J.]] | ||
[[Category: Stammers, D | [[Category: Stammers, D K.]] | ||
[[Category: Stuart, D | [[Category: Stuart, D I.]] | ||
[[Category: GWB]] | [[Category: GWB]] | ||
[[Category: aids]] | [[Category: aids]] | ||
| Line 26: | Line 25: | ||
[[Category: nnrti]] | [[Category: nnrti]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:14:39 2008'' | ||
