5yk3: Difference between revisions

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====

==human Ragulator complex==

== Structural highlights ==

<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a guided tour on the structure components use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance].

<table><tr><td colspan='2'>[[5yk3]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YK3 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=5YK3 FirstGlance].

</td></tr><tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[~~http~~://proteopedia.org/fgij/fg.htm?mol=5yk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yk3 OCA], [~~http~~://pdbe.org/5yk3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5yk3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5yk3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5yk3 ProSAT]</td></tr>

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.01Å</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=5yk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yk3 OCA], [https://pdbe.org/5yk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yk3 RCSB], [https://www.ebi.ac.uk/pdbsum/5yk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yk3 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/LTOR4_HUMAN LTOR4_HUMAN] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.<ref>PMID:22980980</ref>

==See Also==

*[[Ragulator complex 3D structures|Ragulator complex 3D structures]]

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Z~~-disk~~]]

[[Category: Mu Z]]

[[Category: Wu G]]

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-====
+==human Ragulator complex==
-<StructureSection load='5yk3' size='340' side='right'caption='[[5yk3]]' scene=''>
+<StructureSection load='5yk3' size='340' side='right'caption='[[5yk3]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5yk3]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YK3 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5yk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yk3 OCA], [http://pdbe.org/5yk3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yk3 RCSB], [http://www.ebi.ac.uk/pdbsum/5yk3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yk3 ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.01&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yk3 OCA], [https://pdbe.org/5yk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yk3 RCSB], [https://www.ebi.ac.uk/pdbsum/5yk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yk3 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/LTOR4_HUMAN LTOR4_HUMAN] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.<ref>PMID:22980980</ref>
+==See Also==
+*[[Ragulator complex 3D structures|Ragulator complex 3D structures]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Z-disk]]
+[[Category: Mu Z]]
+[[Category: Wu G]]