1cvu: Difference between revisions

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[[Image:1cvu.~~gif~~|left|200px]]

[[Image:1cvu.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2~~'''~~

===CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2===

~~==Overview==~~

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~~Cyclooxygenases are bifunctional enzymes that catalyse the first committed step in the synthesis of prostaglandins, thromboxanes and other eicosanoids.~~ The ~~two known cyclooxygenases isoforms share a high degree of amino-acid sequence similarity~~, ~~structural topology and an identical catalytic mechanism. Cyclooxygenase enzymes catalyse two sequential reactions in spatially distinct~~, ~~but mechanistically coupled active sites. The initial cyclooxygenase reaction converts arachidonic acid (which is achiral)~~ to ~~prostaglandin G2~~ (~~which has five chiral centres)~~. ~~The subsequent peroxidase reaction reduces prostaglandin G2 to prostaglandin H2~~. ~~Here we report~~ the co-~~crystal structures of murine apo~~-~~cyclooxygenase-2 in complex with arachidonic acid and prostaglandin. These structures suggest the molecular basis for the stereospecificity of prostaglandin G2 synthesis.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10811226}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10811226 is the PubMed ID number.

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==About this Structure==

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[[Category: Endoperoxide]]

[[Category: Prostaglandin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 13~~:09:54 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:32:16 2008''

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-[[Image:1cvu.gif|left|200px]]
+{{Seed}}
+[[Image:1cvu.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1cvu|  PDB=1cvu  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2'''
+===CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2===
-==Overview==
+<!--
-Cyclooxygenases are bifunctional enzymes that catalyse the first committed step in the synthesis of prostaglandins, thromboxanes and other eicosanoids. The two known cyclooxygenases isoforms share a high degree of amino-acid sequence similarity, structural topology and an identical catalytic mechanism. Cyclooxygenase enzymes catalyse two sequential reactions in spatially distinct, but mechanistically coupled active sites. The initial cyclooxygenase reaction converts arachidonic acid (which is achiral) to prostaglandin G2 (which has five chiral centres). The subsequent peroxidase reaction reduces prostaglandin G2 to prostaglandin H2. Here we report the co-crystal structures of murine apo-cyclooxygenase-2 in complex with arachidonic acid and prostaglandin. These structures suggest the molecular basis for the stereospecificity of prostaglandin G2 synthesis.
+The line below this paragraph, {{ABSTRACT_PUBMED_10811226}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10811226 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10811226}}
 ==About this Structure==
@@ Line 39: / Line 43: @@
 [[Category: Endoperoxide]]
 [[Category: Prostaglandin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:09:54 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:32:16 2008''