5yow: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
<StructureSection load='5yow' size='340' side='right'caption='[[5yow]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='5yow' size='340' side='right'caption='[[5yow]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5yow]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5yow]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Heartland_virus Heartland virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YOW FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yow OCA], [https://pdbe.org/5yow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yow RCSB], [https://www.ebi.ac.uk/pdbsum/5yow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yow ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/GP_HTRV GP_HTRV] Structural component of the virion that interacts with glycoprotein C (By similarity). It shields the hydrophobic fusion loops of the glycoprotein C, preventing premature fusion (By similarity). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (By similarity). They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after endocytosis of the virion (Probable). Plays a role in the packaging of ribonucleoproteins during virus assembly (By similarity).[UniProtKB:P03518][UniProtKB:P09613][UniProtKB:P21401]<ref>PMID:33561699</ref> Structural component of the virion that interacts with glycoprotein N (By similarity). Acts as a class II fusion protein that is activated upon acidification and subsequent repositioning of the glycoprotein N (PubMed:29070692). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (By similarity). They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after endocytosis of the virion (Probable).[UniProtKB:P03518][UniProtKB:P09613]<ref>PMID:29070692</ref> <ref>PMID:33561699</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 22: | Line 25: | ||
[[Category: Heartland virus]] | [[Category: Heartland virus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chai | [[Category: Chai Y]] | ||
[[Category: Gao | [[Category: Gao F]] | ||
[[Category: Qi | [[Category: Qi JX]] | ||
[[Category: Wu | [[Category: Wu Y]] | ||
