Reverse transcriptase 3D structures

3D Structures of Reverse transcriptase

Updated on 15-February-2022

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• HIV-1 reverse transcriptase P66/P51
  • 3dlk, 1hmv - P66/P51
    
  • 1mu2, 1jle, 1hpz, 1hqu, 1qe1, 1dlo, 2wom, 2won, 3tam, 4dg1, 4zhr, 4ifv - P66/P51 (mutant)
    
  • 3qip - P66/P51 + NNRTI + RNase H inhibitor
    
  • 3irx, 3is9, 3lak, 3lal, 3lam, 3lan, 3ffi, 3di6, 3dle, 3dlg, 2rki, 3c6t, 3c6u, 2rf2, 2vg5, 2vg6, 2vg7, 2opp, 1jlq, 1ep4, 1c0t, 1c0u, 1dtt, 1dtq, 1bqm, 1rt1, 1rt2, 1rev, 1rtj, 1vru, 1hnv, 1hni, 3t19, 5ki4, 5fdl, 5c24, 5c25, 4rw7, 5ter, 5k14, 2ynh, 2yni, 4ncg, 1c1b, 3lp0, 3lp1, 3lp2, 1vrt, 3hvt, 4i7f, 3m8p, 3mec, 3mee, 2zd1, 3qlh, 1ikw, 1fk9, 3dya, 3e01, 3drp - P66/P51+NNRTI
    
  • 1s1t, 1s1v, 1s1w, 1s6p, 1s6q, 1s9e, 1s9g, 1suq, 1sv5, 3dm2, 3dmj, 3dok, 3dol, 2opq, 2opr, 2ops, 2ic3, 2hnz, 1jlg, 1bqn, 1uwb, 1tvr, 3qo9, 3t1a, 5c42, 5tw3, 4rw4, 4rw6, 4rw8, 2ynf, 2yng, 2ynf, 2yng, 4kko, 4lsl, 4lsn, 4mfb, 4o44, 4o4g, 1lw2, 1rt3, 6duh, 6dug, 6duf, 6cgf, 6c0r, 1jla, 6c0p, 6c0o, 6c0n, 6c0l, 6c0k, 6c0j, 5vqz, 5vqy, 5vqx, 5vqw, 5vqv, 5vqu, 5vqt, 5vqs, 5vqr, 5vqq, 6x47, 2ykm, 2ykn, 4h4m, 4h4o, 4rw4, 4rw6, 4rw7, 4rw8, 4rw9, 2iaj, 2hnd, 2hny, 1s1u, 1s1x, 1lw0, 1lwc, 1lwe, 1lwf, 1jlb, 1jlf, 1fkp, 3med, 3meg, 2ze2, 4g1q, 4icl, 4id5, 4idk, 4ify, 4ig0, 4ig3, 4kfb, 1jkh, 1ikv, 1fko, 3drr, 3drs, 6dtw, 6dtx, 6ul5, 2iaj, 6x49, 6x4a, 6x4b, 6x4c, 6x4d, 6x4e, 6x4f - P66/P51 (mutant)+NNRTI
    
  • 4qag – Hiv1P66 + coumarin derivative
    
  • 1rti - P66/P51+ inhibitor
    
  • 3ig1 - P66/P51 + inhibitor beta-thujaplicinol
    
  • 3i0r, 3i0s, 3m8q, 3isn, 3ith, 1c1c, 3nbp, 5vz6 - P66/P51+ pyrimidine derivative
    
  • 1ikx, 4ko0, 4we1, 6aoc, 5tuq, 6oe3 - P66/P51 (mutant)+ pyrimidine derivative
    
  • 1tv6 - P66/P51+ pyridine derivative
    
  • 6eli - P66/P51+ pyridine derivative + rilpivirine + gag-pol polyprotein
    
  • 1jlc, 1iky, 1eet - P66/P51 (mutant) + pyridine derivative
    
  • 5cym, 5cyq - P66/P51 (mutant) + pyrazole derivative
    
  • 2b5j, 2ban, 2be2, 1rth, 4kv8 - P66/P51+ pyridone derivative
    
  • 5j1e, 5hbm - P66/P51 (mutant) + pyridone derivative
    
  • 6ecl - P66/P51 (mutant) + triazole derivative
    
  • 6o9e - P66/P51 (mutant) + pyridone derivative + CMP
    
  • 1tkt, 1tkx, 1tkz, 1tl1, 1tl3 - P66/P51+ quinoline derivative
    
  • 5uv5 - P66/P51 (mutant) + quinoline derivative
    
  • 2b6a - P66/P51+ THR-50
    
  • 2i5j - P66/P51 (mutant)+hydrazone derivative
    
  • 1rt4, 1rt5, 1rt6, 1rt7 - P66/P51+ carboxanilide derivative
    
  • 1klm - P66/P51+piperazine derivative
    
• HIV-1 reverse transcriptase complex with DNA/RNA
  • 3kjv, 3kk3, 1r0a, 1n5y, 1n6q, 1hys, 5d3g, 5i3u - P66/P51+DNA
    
  • 1j5o, 1rtd, 3klf, 3v4i, 3v6d, 6avt, 6avm, 6asw, 5j2q, 5j2p, 5j2m, 6or7, 6otz, 6oun, 6bhj, 6kdj, 6kdk, 6kdm, 6kdn, 6kdo, 6uir, 6uis, 6uit, 6ujx, 6ujy, 6ujz, 6uk0 - P66/P51 (mutant)+DNA
    
  • 4r5p, 5j2n, 5txo, 5txp - P66/P51 (mutant) + nucleotide + DNA
    
  • 3v81 - P66/P51 (mutant) + DNA + NNRTI
    
  • 1hvu - P66/P51+RNA
    
  • 4b3o, 4b3p, 4b3q, 6bsj, 6bsi, 6bsh, 6bsg - P66/P51 + RNA + DNA
    
  • 4pqu - P66/P51 (mutant) + dATP + RNA + DNA
    
  • 5i42 - P66/P51 + dTTP + DNA
    
  • 6anq, 6an8, 6an2, 6amo - P66/P51 (mutant) + dTTP + DNA
    
  • 6p1i, 6p1x, 6p2g - P66/P51 (mutant) + dCTP + DNA
    
  • 6ik9 - P66/P51 (mutant) + dCMP + GTP + DNA
    
  • 5txn, 5txm, 5txl - P66/P51 (mutant) + dATP + DNA
    
  • 6b19 - P66/P51 (mutant) + tRNA + RNA
    
  • 6waz, 6wb0, 6wb1, 6wb2 - P66/P51 (mutant) + tRNA + RNA – Cryo EM
    
  • 4puo, 4pwd, 4q0b - P66/P51 (mutant) + NNRTI + RNA + DNA
    
  • 1t03, 1t05 - P66/P51+DNA+Fab+NNRTI
    
  • 3jsm - P66/P51 (mutant)+DNA+NNRTI
    
  • 2hmi - P66/P51 (mutant)+DNA+Fab
    
  • 3kk1 - P66/P51 (mutant)+DNA + inhibitor
    
  • 3kk2 - P66/P51+DNA+NNRTI
    
  • 3jyt - P66/P51 (mutant)+DNA+NNRTI
    
  • 4r5p, 5hlf, 5hp1, 5hro - P66/P51 + DNA + phosphonate inhibitor
    
• HIV-1 AZT-resistant reverse transcriptase P66/P51
  • 3kli - P66/P51 (mutant)
    
  • 3kle, 3klg, 3klh – P66/P51 (mutant) + DNA
• HIV-1 reverse transcriptase P66
  • 2jle – P66+NNRTI
    
  • 1har - P66 N-terminal
    
  • 5t82 - P66 thumb domain - NMR
    
• Hiv-1 P15
  • 1rdh, 1hrh, 5dzm – P15
    
  • 3lp3 – P15+inhibitor MK3
    
  • 3k2p – P15+inhibitor beta-thujaplicinol
    
  • 3hyf – P15+pyrimidine derivative
    
  • 1o1w – P15+Mg - NMR
    
• HIV-2 reverse transcriptase
  • 1mu2 - RT (mutant)
• Moloney murine leukemia virus reverse transcriptase
  • 1mml - MmlvRT residues 130-394
    
  • 1nnd - MmlvRT catalytic fragment residues 144-398 (mutant)
    
  • 2r2r, 2r2t, 2fjv, 2fjw, 2fjx, 1ztw, 2fvs, 2fvr, 2fvq, 2fvp, 1n4l - MmlvRT catalytic fragment residues 144-398 +DNA
    
  • 2r2s, 2r2u – MmlvRT catalytic fragment residues 144-398 +DNA+Co Bleomycin
    
  • 1ztt – MmlvRT catalytic fragment residues 144-398 +DNA+netropsin
    
  • 3fsi – MmlvRT catalytic fragment residues 144-398 +DNA+trypanocidal
    
  • 2hb5 – MmlvRT RNAse domain residues 618-791
    
  • 4xo0, 4xpc, 4xpe, 5vbs, 4m94, 4m95, 6b1q, 6b1r, 6b1s – MmlvRT catalytic fragment residues 683-937 +DNA
    
  • 4mh8 – MmlvRT P80 residues 683-1330 (mutant)
    
  • 1i6j, 1d0e, 1d1u, 1qaj, 1qai, 6mih, 6mik – MmlvRT N-terminal+DNA
    
• Xenotropic mulv-related virus reverse transcriptase
  • 3v1o, 3v1q – RNAse H domain
    
  • 3v1r – RNAse H domain + inhibitor
    
  • 4hkq – RT residues 658-1328 (mutant) + DNA + RNA
    
• Telomerase reverse transcriptase see Telomerase
• other RT
  • 4ol8 - P55 (mutant) + RNA + DNA - yeast
    
  • 6me0, 6mec - P55 + RNA + DNA – Thermosynechococcus elongatus – Cryo EM
    
  • 2lsn – RT – Simian foamy virus – NMR
    

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Michal Harel, Joel L. Sussman