Virus protease

spinqualitylabelsall models Structure of human rhinovirus 3C protease complex with inhibitor (PDB entry 1cqq) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Virus protease or 3C protease or virus proteinase are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes. F Disease Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus. Coxsakievirus causes the human diseases myocarditis and pericarditis. Structural highlights Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The active site triad contains Cys147, His40 and Glu71 (PDB entry 1cqq). Whole binding site. See also Immunodeficiency virus protease Human Immunodeficiency Virus HIV-1 protease HIV Protease Inhibitor Pharmacokinetics HIV Protease Inhibitor Resistance Profile HIV Protease Resistance Molecular Playground/Dengue Virus Protease Viability of a drug-resistant HIV-1 protease mutant Molecular Playground/Dengue Virus Protease FMDV 3C for Foot-and-Mouth virus protease SARS Coronavirus Main Proteinase 3D Structures of Virus protease Virus protease 3D structures

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Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman