6jvo: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal structure of human MTH1 in complex with compound MI1022== | ==Crystal structure of human MTH1 in complex with compound MI1022== | ||
<StructureSection load='6jvo' size='340' side='right'caption='[[6jvo]]' scene=''> | <StructureSection load='6jvo' size='340' side='right'caption='[[6jvo]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JVO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6JVO FirstGlance]. <br> | <table><tr><td colspan='2'>[[6jvo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JVO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6JVO FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6jvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jvo OCA], [http://pdbe.org/6jvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jvo RCSB], [http://www.ebi.ac.uk/pdbsum/6jvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jvo ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CJ6:N4-cyclopropyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine'>CJ6</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUDT1, MTH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6jvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jvo OCA], [http://pdbe.org/6jvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jvo RCSB], [http://www.ebi.ac.uk/pdbsum/6jvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jvo ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cheng | [[Category: Cheng, Y S]] | ||
[[Category: Li | [[Category: Li, Y H]] | ||
[[Category: Peng C]] | [[Category: Peng, C]] | ||
[[Category: 8-oxo-dgtp]] | |||
[[Category: Hydrolase]] | |||
[[Category: Inhibitor development]] | |||
[[Category: Mth1]] | |||
[[Category: Oxidative dna damage]] | |||
