7k7z: Difference between revisions

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====

==Structure of a hit for G Protein Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure==

== Structural highlights ==

<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a guided tour on the structure components use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance].

<table><tr><td colspan='2'>[[7k7z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K7Z OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=7K7Z FirstGlance].

</td></tr><tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[~~http~~://proteopedia.org/fgij/fg.htm?mol=7k7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k7z OCA], [~~http~~://pdbe.org/7k7z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7k7z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7k7z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7k7z ProSAT]</td></tr>

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.606087Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=W4G:3-benzyl-7-(1H-pyrazol-4-yl)quinazolin-4(3H)-one'>W4G</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7k7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k7z OCA], [https://pdbe.org/7k7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k7z RCSB], [https://www.ebi.ac.uk/pdbsum/7k7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k7z ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/ARBK1_HUMAN ARBK1_HUMAN] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.<ref>PMID:19306925</ref>

==See Also==

*[[Beta adrenergic receptor kinase 3D structures|Beta adrenergic receptor kinase 3D structures]]

*[[Transducin 3D structures|Transducin 3D structures]]

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: ~~Z-disk~~]]

[[Category: Milligan C]]

[[Category: Spurlino JC]]

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-====
+==Structure of a hit for G Protein Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure==
-<StructureSection load='7k7z' size='340' side='right'caption='[[7k7z]]' scene=''>
+<StructureSection load='7k7z' size='340' side='right'caption='[[7k7z]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
+<table><tr><td colspan='2'>[[7k7z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K7Z FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7k7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k7z OCA], [http://pdbe.org/7k7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7k7z RCSB], [http://www.ebi.ac.uk/pdbsum/7k7z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7k7z ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.606087&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=W4G:3-benzyl-7-(1H-pyrazol-4-yl)quinazolin-4(3H)-one'>W4G</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k7z OCA], [https://pdbe.org/7k7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k7z RCSB], [https://www.ebi.ac.uk/pdbsum/7k7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k7z ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/ARBK1_HUMAN ARBK1_HUMAN] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.<ref>PMID:19306925</ref>
+==See Also==
+*[[Beta adrenergic receptor kinase 3D structures|Beta adrenergic receptor kinase 3D structures]]
+*[[Transducin 3D structures|Transducin 3D structures]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Z-disk]]
+[[Category: Milligan C]]
+[[Category: Spurlino JC]]