6ats: Difference between revisions

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<StructureSection load='6ats' size='340' side='right'caption='[[6ats]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='6ats' size='340' side='right'caption='[[6ats]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6ats]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hetfu Hetfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ATS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ATS FirstGlance]. <br>
<table><tr><td colspan='2'>[[6ats]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chersonesometrus_fulvipes Chersonesometrus fulvipes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ATS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ATS FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6atl|6atl]], [[6atm|6atm]], [[6atn|6atn]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ats FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ats OCA], [http://pdbe.org/6ats PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ats RCSB], [http://www.ebi.ac.uk/pdbsum/6ats PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ats ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ats FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ats OCA], [https://pdbe.org/6ats PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ats RCSB], [https://www.ebi.ac.uk/pdbsum/6ats PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ats ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KKX12_HETFU KKX12_HETFU]] Voltage-gated potassium channel blocker.[UniProtKB:P82850]
[https://www.uniprot.org/uniprot/KKX11_CHEFU KKX11_CHEFU] Shows weak blocking activity on voltage-gated potassium channels Kv10.1/KCNH1/EAG1 (IC(50)=26 uM), Kv1.2/KCNA2 (Kd=150 uM), Kv1.3/KCNA3 (Kd=40 uM), Kv1.6/KCNA3 (16.6% inhibition at 40 uM toxin) (PubMed:12034709, PubMed:23726856, PubMed:27578329). The block is dose-dependent, voltage-independent, and reversible (PubMed:12034709). Also shows a weak inhibitory activity on the plant pathogen F.culmorum growth (IC(50)=18.8-37.7 uM) (PubMed:27578329).<ref>PMID:12034709</ref> <ref>PMID:23726856</ref> <ref>PMID:27578329</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hetfu]]
[[Category: Chersonesometrus fulvipes]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Gewe, M M]]
[[Category: Gewe MM]]
[[Category: Rupert, P]]
[[Category: Rupert P]]
[[Category: Strong, R K]]
[[Category: Strong RK]]
[[Category: Cystine knot]]
[[Category: Knottin]]
[[Category: Toxin]]
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