1cyq: Difference between revisions

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[[Image:1cyq.gif|left|200px]]
{{Seed}}
[[Image:1cyq.png|left|200px]]


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{{STRUCTURE_1cyq|  PDB=1cyq  |  SCENE=  }}  
{{STRUCTURE_1cyq|  PDB=1cyq  |  SCENE=  }}  


'''INTRON ENCODED HOMING ENDONUCLEASE I-PPOI (H98A)/DNA HOMING SITE COMPLEX'''
===INTRON ENCODED HOMING ENDONUCLEASE I-PPOI (H98A)/DNA HOMING SITE COMPLEX===




==Overview==
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A novel mechanism of DNA endonucleolytic cleavage has been visualized for the homing endonuclease I-PpoI by trapping the uncleaved enzyme-substrate complex and comparing it to the previously visualized product complex. This enzyme employs a unique single metal mechanism. A magnesium ion is coordinated by an asparagine residue and two DNA oxygen atoms and stabilizes the phosphoanion transition state and the 3'oxygen leaving group. A hydrolytic water molecule is activated by a histidine residue for an in-line attack on the scissile phosphate. A strained enzyme-substrate-metal complex is formed before cleavage, then relaxed during the reaction.
The line below this paragraph, {{ABSTRACT_PUBMED_10581547}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10581547 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10581547}}


==About this Structure==
==About this Structure==
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[[Category: His-cys box zinc binding site]]
[[Category: His-cys box zinc binding site]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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