Sandbox Reserved 1632: Difference between revisions
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== Function of your Protein == | == Function of your Protein == | ||
<scene name='86/861614/Protein_view_1/1'>This is an adhesion protein</scene> it binds to a host cell (human epithelial cell) to provide a host cell recognition to invade the human cell. | <scene name='86/861614/Protein_view_1/1'>This is an adhesion protein</scene> it binds to a host cell (human epithelial cell) to provide a host cell recognition to invade the human cell. In this case, these epithelial adhesions are adhering Candida glabrata to a human epithelial cell. | ||
== Biological relevance and broader implications == | == Biological relevance and broader implications == | ||
Candida glabrata is a fungus that is able to infect a human host through the bloodstream. Unfortunately, this is a life-threatening infection for humans. By trying to understand the structure of the epithelial adhesion on the outer surface of the fungus. There could be a possibility of stoping the adhesion from attaching to the host cell and stop host cell recognition altogether. This could help in lowering the high amount of cases that are life-threatening as there are upwards of 29% of cases. | |||
== Important amino acids == | == Important amino acids == | ||
The type of protein that we are looking at is an adhesion protein, so it does not function as an enzyme. It does not have a catalytic triad within the active site. Though there are some important amino acid residues to highlight as they interact with the ligand (lactose). In the diagram of the protein, we can look to see the red ball stick structures by the ligand are the amino acid residues interacting with the ligand. <scene name='86/861614/Protein_view_2/5'>These would be Arg258, Asp257, Asp196, and Asp197.</scene> They are all interacting via hydrogen bonds. | The type of protein that we are looking at is an adhesion protein, so it does not function as an enzyme. It does not have a catalytic triad within the active site. Though there are some important amino acid residues to highlight as they interact with the ligand (lactose). In the diagram of the protein, we can look to see the red ball stick structures by the ligand are the amino acid residues interacting with the ligand. <scene name='86/861614/Protein_view_2/5'>These would be Arg258, Asp257, Asp196, and Asp197.</scene> They are all interacting via hydrogen bonds. | ||
== Structural highlights == | == Structural highlights == | ||
Some things to note are the | |||
== Other important features == | == Other important features == | ||
