Sandbox GGC11: Difference between revisions

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== Structural highlights ==
== Structural highlights ==


This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<scene name='78/781195/Aa_116/3'>Arg 116</scene>this is the right one


This structure highlight shows where <scene name='78/781195/2klrarg_116/1'>Arg 116</scene> is located in the A chain. A mutation of this amino acid to cysteine will lead to cataracts. <ref name="alpha" />
This structure highlight shows where <scene name='78/781195/2klrarg_116/1'>Arg 116</scene> is located in the A chain. A mutation of this amino acid to cysteine will lead to cataracts. <ref name="alpha" />
The following structure shows where <scene name='78/781195/Arginine120b/1'>Arginine 120 on B chain</scene> is located. The mutation of this amino acid in the B chain of crystalline gene decreased interaction with wild-type CRYAA and CRYAB. However, it increases interactions with CRBB2 and CRYGC leading to cytoplasmic aggregation. <ref>PMID:12601044</ref>
The following structure shows where <scene name='78/781195/Arginine120b/1'>Arginine 120 on B chain</scene> is located. The mutation of this amino acid in the B chain of crystalline gene decreased interaction with wild-type CRYAA and CRYAB. However, it increases interactions with CRBB2 and CRYGC leading to cytoplasmic aggregation. <ref>PMID:12601044</ref>


This highlight shows the location of the <scene name='78/781195/His_ab/1'>HIS amino acids </scene> involved in inter-subunit bridging of Zn ions which enhances stability.<ref>PMID:22890888</ref> This is crucial as there is no protein turnover in the lens.  
This highlight shows the location of the <scene name='78/781195/His_ab/1'>HIS amino acids </scene> involved in inter-subunit bridging of Zn ions which enhances stability.<ref>PMID:22890888</ref> This is crucial as there is no protein turnover in the lens.  


The following structure shows <scene name='78/781195/Crystallin/1'>Alpha Crystallin Structure</scene> with all the chains that make it up.
</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>
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