1d0b: Difference between revisions

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[[Image:1d0b.jpg|left|200px]]
{{Seed}}
[[Image:1d0b.png|left|200px]]


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{{STRUCTURE_1d0b|  PDB=1d0b  |  SCENE=  }}  
{{STRUCTURE_1d0b|  PDB=1d0b  |  SCENE=  }}  


'''INTERNALIN B LEUCINE RICH REPEAT DOMAIN'''
===INTERNALIN B LEUCINE RICH REPEAT DOMAIN===




==Overview==
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The L. monocytogenes protein lnlB activates phosphoinositide 3-kinase and induces phagocytosis in several mammalian cell types. The 1.86 A resolution X-ray crystal structure of the leucine-rich repeat domain of lnlB that is both necessary and sufficient to induce phagocytosis is presented here. The structure supports a crucial role for calcium in host cell invasion by L. monocytogenes and supplies a rationale for its function. Calciums are bound to the protein in an unusually exposed manner that suggests that the metals may act as a bridge between lnlB and mammalian cell surface receptors. The structure also identifies surfaces on the curved and elongated molecule that may constitute additional interaction sites in forming a bacterial-mammalian signaling complex.
The line below this paragraph, {{ABSTRACT_PUBMED_10635330}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10635330 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10635330}}


==About this Structure==
==About this Structure==
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[[Category: Calcium binding]]
[[Category: Calcium binding]]
[[Category: Leucine rich repeat]]
[[Category: Leucine rich repeat]]
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