6pd7: Difference between revisions
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<StructureSection load='6pd7' size='340' side='right'caption='[[6pd7]], [[Resolution|resolution]] 1.92Å' scene=''> | <StructureSection load='6pd7' size='340' side='right'caption='[[6pd7]], [[Resolution|resolution]] 1.92Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6pd7]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6pd7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PD7 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OAJ:(3R)-4-{[4-(4-cyano-3-methylphenoxy)phenyl]acetyl}morpholine-3-carboxylic+acid'>OAJ</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pd7 OCA], [https://pdbe.org/6pd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pd7 RCSB], [https://www.ebi.ac.uk/pdbsum/6pd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pd7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Escherichia coli K-12]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bentley | [[Category: Bentley M]] | ||
[[Category: Doak | [[Category: Doak B]] | ||
[[Category: Ilyichova | [[Category: Ilyichova OV]] | ||
[[Category: Scanlon | [[Category: Scanlon MJ]] | ||
Revision as of 07:27, 11 October 2023
Crystal Structure of EcDsbA in a complex with purified morpholine carboxylic acid 7
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