Sandbox GGC11: Difference between revisions
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The following structure shows where <scene name='78/781195/Arginine120b/1'>Arginine 120 on B chain</scene> is located. The mutation of this amino acid in the B chain of crystalline gene decreased interaction with wild-type CRYAA and CRYAB. However, it increases interactions with CRBB2 and CRYGC leading to cytoplasmic aggregation. <ref>PMID:12601044</ref> | The following structure shows where <scene name='78/781195/Arginine120b/1'>Arginine 120 on B chain</scene> is located. The mutation of this amino acid in the B chain of crystalline gene decreased interaction with wild-type CRYAA and CRYAB. However, it increases interactions with CRBB2 and CRYGC leading to cytoplasmic aggregation. <ref>PMID:12601044</ref> | ||
This highlight shows the location of the <scene name='78/781195/ | This highlight shows the location of the <scene name='78/781195/His_abr/1'>Histidine amino acids</scene> involved in inter-subunit bridging of Zn ions which enhances stability.<ref>PMID:22890888</ref> This is crucial as there is no protein turnover in the lens. | ||
The following structure shows <scene name='78/781195/Crystallin/1'>Alpha Crystallin Structure</scene> with all the chains that make it up. | The following structure shows <scene name='78/781195/Crystallin/1'>Alpha Crystallin Structure</scene> with all the chains that make it up. | ||
