Sandbox GGC3: Difference between revisions

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== Relevance ==
== Relevance ==
The two subunits of the s-protein ; S1 and S2 interact with other proteins like the 3a and 7a on the SARS-COV-2. The s-protein has other protein modifications such as the amino acid modification in which there is a disulfide bond, Glycosylation with an N-liked to asparagine of the host cell . There is also a post-translation modification where the Spike glycoprotein is digested within host endosomes <ref> https://www.uniprot.org/uniprot/P59594.  
The two subunits of the s-protein ; S1 and S2 interact with other proteins like the 3a and 7a on the SARS-COV-2. The s-protein has other protein modifications such as the amino acid modification in which there is a disulfide bond, Glycosylation with an N-liked to asparagine of the host cell . There is also a post-translation modification where the Spike glycoprotein is digested within host endosomes <ref> https://www.uniprot.org/uniprot/P59594.  
  Aside the modifications of the s-protein, this protein is related to other porteins shown in the blast below.
   
[[Image:Picture1.jpg]]
 
A phylogenetic tree made from the most closet proteins shown below.
[[Image:Picture2.jpg]]


== Structural highlights ==
== Structural highlights ==


This is a sample scene created with SAT to NTD -CT<scene name='75/752266/Ntd_-_ct/1'>S1 subunit is in the downstream of NTD and S2 subunit is in the upsteam of CT</scene><ref>doi.org/10.1016/j.ijid.2020.10.033 .Val367<scene name='75/752266/Val367/1'>Binding region val367</scene><ref>6. China National Center for Bioinformation 2019 Novel Coronavirus Resource. (n.d.). Retrieved November 13, 2020, from https://bigd.big.ac.cn/ncov/protein?lang=en .  D614 <scene name='75/752266/Asp_614/1'>The Mutation site D614 </scene><ref>doi.org/10.1016/j.ijid.2020.10.033. LYS 187 <scene name='75/752266/Lys_187/1'>The Receptor Binding Domain (RBD)</scene>.ALA 668 <scene name='75/752266/Ala_668/1'>Furin Cleavage site</scene> <ref>https://doi.org/10.1016/j.virol.2006.02.003.
NTD -CT<scene name='75/752266/Ntd_-_ct/1'>S1 subunit is in the downstream of NTD and S2 subunit is in the upsteam of CT</scene> .Val367<scene name='75/752266/Val367/1'>Binding region val367</scene> .  D614 <scene name='75/752266/Asp_614/1'>The Mutation site D614 </scene>. LYS 187 <scene name='75/752266/Lys_187/1'>The Receptor Binding Domain (RBD)</scene>.ALA 668 <scene name='75/752266/Ala_668/1'>Furin Cleavage site</scene>  
 
</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>
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