Sandbox GGC6: Difference between revisions
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This is hereditary disease which insoluble amyloid proteins deposits in body tissues and organs. This tends to abnormal protein build-up and leads to damaged organs and deaths. The disease is caused by a mutation fibrinogen alpha chain.<ref>PMID: 23227278</ref> | This is hereditary disease which insoluble amyloid proteins deposits in body tissues and organs. This tends to abnormal protein build-up and leads to damaged organs and deaths. The disease is caused by a mutation fibrinogen alpha chain.<ref>PMID: 23227278</ref> | ||
This disease does not show symptoms at first stage. when it gets relatively advanced, the symptoms can be lack of appetite, weight loss, fatigue, weakness, shortness of breath, etc. Due to abnormal protein build-up in body organs, organs can be affected such as heart, liver, kidney, skin, etc. This leads to cardiomyopathy, liver failure, skin rash, nephrotic syndrome. However, nervous system is not affected. There is no treatment for this disease <ref> | |||
== Structural highlights == | == Structural highlights == | ||
