Sandbox GGC11: Difference between revisions

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This structure highlight shows where <scene name='78/781195/2klrarg_116/1'>Arg 116</scene> is located in the A chain. A mutation of this amino acid to cysteine will lead to cataracts. <ref name="alpha" />

This structure highlight shows where <scene name='78/781195/2klrarg_116/2'>Arg 116</scene> is located in the A chain. A mutation of this amino acid to cysteine will lead to cataracts. <ref name="alpha" />

The following structure shows where <scene name='78/781195/Arginine120b/2'>Arginine 120 on B chain</scene> is located. The mutation of this amino acid in the B chain of crystalline gene decreased interaction with wild-type CRYAA and CRYAB. However, it increases interactions with CRBB2 and CRYGC leading to cytoplasmic aggregation. <ref>PMID:12601044</ref> Also, when Arg is mutated to Gly, it causes desmin- related myopathy, cardiomyopathy, and cataracts. Also, this mutation reduces chaperone protection activity and in some target proteins promoted aggregation. <ref name="alpha" />

Sandbox GGC11: Difference between revisions

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Revision as of 03:47, 15 November 2020 view source Student (talk \| contribs) students 33,923 edits No edit summary ← Older edit		Revision as of 19:45, 15 November 2020 view source Student (talk \| contribs) students 33,923 edits No edit summary Newer edit →
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	This structure highlight shows where <scene name='78/781195/2klrarg_116/1'>Arg 116</scene> is located in the A chain. A mutation of this amino acid to cysteine will lead to cataracts. <ref name="alpha" />		This structure highlight shows where <scene name='78/781195/2klrarg_116/2'>Arg 116</scene> is located in the A chain. A mutation of this amino acid to cysteine will lead to cataracts. <ref name="alpha" />

	The following structure shows where <scene name='78/781195/Arginine120b/2'>Arginine 120 on B chain</scene> is located. The mutation of this amino acid in the B chain of crystalline gene decreased interaction with wild-type CRYAA and CRYAB. However, it increases interactions with CRBB2 and CRYGC leading to cytoplasmic aggregation. <ref>PMID:12601044</ref> Also, when Arg is mutated to Gly, it causes desmin- related myopathy, cardiomyopathy, and cataracts. Also, this mutation reduces chaperone protection activity and in some target proteins promoted aggregation. <ref name="alpha" />		The following structure shows where <scene name='78/781195/Arginine120b/2'>Arginine 120 on B chain</scene> is located. The mutation of this amino acid in the B chain of crystalline gene decreased interaction with wild-type CRYAA and CRYAB. However, it increases interactions with CRBB2 and CRYGC leading to cytoplasmic aggregation. <ref>PMID:12601044</ref> Also, when Arg is mutated to Gly, it causes desmin- related myopathy, cardiomyopathy, and cataracts. Also, this mutation reduces chaperone protection activity and in some target proteins promoted aggregation. <ref name="alpha" />