Sandbox GGC7: Difference between revisions
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== Function == | == Function == | ||
Once the insulin molecule enters the active site and is recognized, the enzyme begins to unfold the insulin and makes initial cleavages in the middle of both the A and B chains. The enzyme then makes six more cleavages. One cleavage site right next to the first one on the A chain and 5 more on the B chain <ref>DOI 10.1074/jbc.M900068200</ref>. Three near the middle and two near the C-terminus. There are no cleavage sites that are near the N-terminus of either chain. | Once the insulin molecule enters the active site and is recognized, the enzyme changes conformation from the open state to the closed state and begins to unfold the insulin and makes initial cleavages in the middle of both the A and B chains. The enzyme then makes six more cleavages. One cleavage site right next to the first one on the A chain and 5 more on the B chain <ref>DOI 10.1074/jbc.M900068200</ref>. Three near the middle and two near the C-terminus. There are no cleavage sites that are near the N-terminus of either chain. | ||
== Disease == | == Disease == | ||
