Sandbox GGC11: Difference between revisions
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== Relevance == | == Relevance == | ||
Alpha Crystallin A 1-172 is found at nearly 2 folds higher in diabetic lenses than an aged matched control lens. In humans, the alpha A gene is found in chromosome 21 and encodes for 173 amino acid residues while the alpha B gene is found in chromosome 11 and encodes for 175 amino acids.<ref name="alpha" /> In mammalian lens, the molar ratio between alpha A and alpha B is a 3 to 1 ratio. <ref>PMID:20836128</ref> | Alpha Crystallin A 1-172 is found at nearly 2 folds higher in diabetic lenses than an aged matched control lens. In humans, the alpha A gene is found in chromosome 21 and encodes for 173 amino acid residues while the alpha B gene is found in chromosome 11 and encodes for 175 amino acids.<ref name="alpha" /> In mammalian lens, the molar ratio between alpha A and alpha B is a 3 to 1 ratio. <ref>PMID:20836128</ref> During aging, the eye lens undergo post translational modification that can affect the transparency of the lens. There is an increase in the high molecular weight fraction and water soluble to insoluble fraction. <ref name="alpha" /> Due to the function of alpha crystallin a and b, all of this changes can occur without affecting the transparency of the eye lens. | ||
Furthermore, an increased level of Alpha Crystallin B chain has been associated with various diseases such Alexander's disease, Alzheimer's, and Parkinson's. <ref>PMID:8256860</ref> | |||
== Structural highlights == | == Structural highlights == | ||
