Sandbox GGC1: Difference between revisions
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'''Histone H3.3'''<StructureSection load='3WTP' size='340' side='right' caption='Caption for this structure' scene=''> | '''Histone H3.3'''<StructureSection load='3WTP' size='340' side='right' caption='Caption for this structure' scene=''> | ||
== Introduction == | == Introduction == | ||
Histone H3.3 is a variant histone of H3 which has the gene name H3.3A and this particular protein is found in Humans. | Histone H3.3 is a variant histone of H3 which has the gene name H3.3A and this particular protein is found in Humans. The location of this can be found in the nucleus and in the chromosome.<ref>https://www.uniprot.org/uniprot/P84243</ref> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/P84243 Histone H3] replaces H3 in a range of nucleosomes in active genes and it takes over the original H3 in non dividing cells. Nucleosomes wrap around and compact DNA into chromatin which limits DNA access to cellular machineries which need DNA as a template. Histones play an important role in regulation of transcription, DNA repair, DNA replication and also chromosomal stability. Access to DNA is regulated by post-translational modifications of histones which is called a histone code, and nucleosome remodeling. It also serves as a replacement histone that's imbedded chromatin regions by the HIRA chaperone, after the depletion of the H3.1 during transcription and DNA repair.<ref>https://www.uniprot.org/uniprot/P84243</ref> | [https://www.uniprot.org/uniprot/P84243 Histone H3] replaces H3 in a range of nucleosomes in active genes and it takes over the original H3 in non dividing cells. Nucleosomes wrap around and compact DNA into chromatin which limits DNA access to cellular machineries which need DNA as a template. Histones play an important role in regulation of transcription, DNA repair, DNA replication and also chromosomal stability. Access to DNA is regulated by post-translational modifications of histones which is called a histone code, and nucleosome remodeling. It also serves as a replacement histone that's imbedded chromatin regions by the HIRA chaperone, after the depletion of the H3.1 during transcription and DNA repair.<ref>https://www.uniprot.org/uniprot/P84243</ref> | ||
