1d24: Difference between revisions

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[[Image:1d24.~~jpg~~|left|200px]]

[[Image:1d24.png|left|200px]]

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~~'''~~CRYSTAL AND MOLECULAR STRUCTURE OF A DNA DUPLEX CONTAINING THE CARCINOGENIC LESION O6-METHYLGUANINE~~'''~~

===CRYSTAL AND MOLECULAR STRUCTURE OF A DNA DUPLEX CONTAINING THE CARCINOGENIC LESION O6-METHYLGUANINE===

~~==Overview==~~

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The ~~crystal and molecular structure of~~ the ~~first DNA duplex containing the carcinogenic lesion O6MeG has been determined~~ to ~~a resolution of 1.9 A and refined to an R factor of 19%. (d[CGC-(O6Me)GCG])2 crystallizes in~~ the ~~left-handed Z DNA form and has crystal parameters and conformational features similar to those of the parent sequence [d~~(~~CG)3]2. The methyl groups~~ on ~~O6 of G4 and G10 have C5-C6-O6-O6Me torsion angles of 73 degrees and 56 degrees, respectively, and protrude onto the major groove surface~~. ~~The base-pairing conformation for the methylated G~~.~~C base pairs~~ is of the ~~Watson~~-~~Crick type as opposed to a wobble~~-~~type conformation that had been proposed in a B DNA fragment. As in other Z DNA structures, a spine of hydration is seen in the minor groove.~~

The line below this paragraph, {{ABSTRACT_PUBMED_2271657}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 2271657 is the PubMed ID number.

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==About this Structure==

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[[Category: Modified]]

[[Category: Z-dna]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 13~~:21:52 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:09:55 2008''

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-[[Image:1d24.jpg|left|200px]]
+{{Seed}}
+[[Image:1d24.png|left|200px]]
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 {{STRUCTURE_1d24|  PDB=1d24  |  SCENE=  }}
-'''CRYSTAL AND MOLECULAR STRUCTURE OF A DNA DUPLEX CONTAINING THE CARCINOGENIC LESION O6-METHYLGUANINE'''
+===CRYSTAL AND MOLECULAR STRUCTURE OF A DNA DUPLEX CONTAINING THE CARCINOGENIC LESION O6-METHYLGUANINE===
-==Overview==
+<!--
-The crystal and molecular structure of the first DNA duplex containing the carcinogenic lesion O6MeG has been determined to a resolution of 1.9 A and refined to an R factor of 19%. (d[CGC-(O6Me)GCG])2 crystallizes in the left-handed Z DNA form and has crystal parameters and conformational features similar to those of the parent sequence [d(CG)3]2. The methyl groups on O6 of G4 and G10 have C5-C6-O6-O6Me torsion angles of 73 degrees and 56 degrees, respectively, and protrude onto the major groove surface. The base-pairing conformation for the methylated G.C base pairs is of the Watson-Crick type as opposed to a wobble-type conformation that had been proposed in a B DNA fragment. As in other Z DNA structures, a spine of hydration is seen in the minor groove.
+The line below this paragraph, {{ABSTRACT_PUBMED_2271657}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 2271657 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_2271657}}
 ==About this Structure==
@@ Line 27: / Line 31: @@
 [[Category: Modified]]
 [[Category: Z-dna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:21:52 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:09:55 2008''