6m5d: Difference between revisions
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==Human serum albumin (apo form)== | ==Human serum albumin (apo form)== | ||
<StructureSection load='6m5d' size='340' side='right'caption='[[6m5d]]' scene=''> | <StructureSection load='6m5d' size='340' side='right'caption='[[6m5d]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M5D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6M5D FirstGlance]. <br> | <table><tr><td colspan='2'>[[6m5d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M5D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6M5D FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6m5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m5d OCA], [http://pdbe.org/6m5d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m5d RCSB], [http://www.ebi.ac.uk/pdbsum/6m5d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m5d ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6m5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m5d OCA], [http://pdbe.org/6m5d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m5d RCSB], [http://www.ebi.ac.uk/pdbsum/6m5d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m5d ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ito S]] | [[Category: Ito, S]] | ||
[[Category: Nagatoishi S]] | [[Category: Nagatoishi, S]] | ||
[[Category: Senoo A]] | [[Category: Senoo, A]] | ||
[[Category: Tsumoto K]] | [[Category: Tsumoto, K]] | ||
[[Category: Wakui N]] | [[Category: Wakui, N]] | ||
[[Category: Yamamoto M]] | [[Category: Yamamoto, M]] | ||
[[Category: Cyclic peptide]] | |||
[[Category: Peptide binding protein]] | |||
[[Category: Transporter]] | |||
