1d2q: Difference between revisions

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[[Image:1d2q.gif|left|200px]]
{{Seed}}
[[Image:1d2q.png|left|200px]]


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{{STRUCTURE_1d2q|  PDB=1d2q  |  SCENE=  }}  
{{STRUCTURE_1d2q|  PDB=1d2q  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF HUMAN TRAIL'''
===CRYSTAL STRUCTURE OF HUMAN TRAIL===




==Overview==
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TRAIL is a newly identified cytokine belonging to the large tumor necrosis factor (TNF) family. TRAIL is a novel molecule inducing apoptosis in a wide variety of tumor cells but not in normal cells. To help in elucidating its biological roles and designing mutants with improved therapeutic potential, we have determined the crystal structure of human TRAIL. The structure reveals that a unique frame insertion of 12-16 amino acids adopts a salient loop structure penetrating into the receptor-binding site. The loop drastically alters the common receptor-binding surface of the TNF family most likely for the specific recognition of cognate partners. A structure-based mutagenesis study demonstrates a critical role of the insertion loop in the cytotoxic activity of TRAIL.
The line below this paragraph, {{ABSTRACT_PUBMED_10485660}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10485660 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10485660}}


==About this Structure==
==About this Structure==
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[[Category: Cytokine]]
[[Category: Cytokine]]
[[Category: Trail]]
[[Category: Trail]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:23:04 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:13:35 2008''
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