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==Crystal structure of Escherichia coli Orotate Phosphoribosyltransferase with an empty active site at 1.55 Angstrom resolution==
==Crystal structure of Escherichia coli Orotate Phosphoribosyltransferase with an empty active site at 1.55 Angstrom resolution==
<StructureSection load='6tai' size='340' side='right'caption='[[6tai]]' scene=''>
<StructureSection load='6tai' size='340' side='right'caption='[[6tai]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TAI FirstGlance]. <br>
<table><tr><td colspan='2'>[[6tai]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TAI FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tai OCA], [http://pdbe.org/6tai PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tai RCSB], [http://www.ebi.ac.uk/pdbsum/6tai PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tai ProSAT]</span></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pyrE, b3642, JW3617 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Orotate_phosphoribosyltransferase Orotate phosphoribosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.10 2.4.2.10] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tai OCA], [https://pdbe.org/6tai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tai RCSB], [https://www.ebi.ac.uk/pdbsum/6tai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tai ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/PYRE_ECOLI PYRE_ECOLI]] Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity).<ref>PMID:8620002</ref> 
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Fernandez FJ]]
[[Category: Orotate phosphoribosyltransferase]]
[[Category: Gomez S]]
[[Category: Fernandez, F J]]
[[Category: Lopez-Estepa M]]
[[Category: Gomez, S]]
[[Category: Navas-Yuste S]]
[[Category: Lopez-Estepa, M]]
[[Category: Vega MC]]
[[Category: Navas-Yuste, S]]
[[Category: Vega, M C]]
[[Category: Transferase]]
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