1d2z: Difference between revisions

Line 1:

[[Image:1d2z.~~gif~~|left|200px]]

[[Image:1d2z.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~THREE-DIMENSIONAL STRUCTURE OF A COMPLEX BETWEEN THE DEATH DOMAINS OF PELLE AND TUBE~~'''~~

===THREE-DIMENSIONAL STRUCTURE OF A COMPLEX BETWEEN THE DEATH DOMAINS OF PELLE AND TUBE===

~~==Overview==~~

<!--

The ~~interaction of~~ the ~~serine/threonine kinase Pelle and adaptor protein Tube through their N-terminal death domains leads~~ to the ~~nuclear translocation of the transcription factor Dorsal and activation of zygotic patterning genes during Drosophila embryogenesis~~. Crystal structure of the Pelle and Tube death domain heterodimer reveals that the two death domains adopt a six-helix bundle fold and are arranged in an open-ended linear array with plastic interfaces mediating their interactions. ~~The Tube death domain has an insertion between helices 2 and 3~~, ~~and a C-terminal tail making significant and indispensable contacts in the heterodimer. In vivo assays of Pelle and Tube mutants confirmed that the integrity of the major heterodimer interface~~ is ~~critical to~~ the ~~activity of these molecules~~.

The line below this paragraph, {{ABSTRACT_PUBMED_10589682}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10589682 is the PubMed ID number.

-->

==About this Structure==

Line 30:

Line 34:

[[Category: Plastic interface]]

[[Category: Six-helix bundle]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 13~~:23:36 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:14:55 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1d2z.gif|left|200px]]
+{{Seed}}
+[[Image:1d2z.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1d2z|  PDB=1d2z  |  SCENE=  }}
-'''THREE-DIMENSIONAL STRUCTURE OF A COMPLEX BETWEEN THE DEATH DOMAINS OF PELLE AND TUBE'''
+===THREE-DIMENSIONAL STRUCTURE OF A COMPLEX BETWEEN THE DEATH DOMAINS OF PELLE AND TUBE===
-==Overview==
+<!--
-The interaction of the serine/threonine kinase Pelle and adaptor protein Tube through their N-terminal death domains leads to the nuclear translocation of the transcription factor Dorsal and activation of zygotic patterning genes during Drosophila embryogenesis. Crystal structure of the Pelle and Tube death domain heterodimer reveals that the two death domains adopt a six-helix bundle fold and are arranged in an open-ended linear array with plastic interfaces mediating their interactions. The Tube death domain has an insertion between helices 2 and 3, and a C-terminal tail making significant and indispensable contacts in the heterodimer. In vivo assays of Pelle and Tube mutants confirmed that the integrity of the major heterodimer interface is critical to the activity of these molecules.
+The line below this paragraph, {{ABSTRACT_PUBMED_10589682}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10589682 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10589682}}
 ==About this Structure==
@@ Line 30: / Line 34: @@
 [[Category: Plastic interface]]
 [[Category: Six-helix bundle]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:23:36 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:14:55 2008''