1d32: Difference between revisions

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[[Image:1d32.jpg|left|200px]]
{{Seed}}
[[Image:1d32.png|left|200px]]


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{{STRUCTURE_1d32|  PDB=1d32  |  SCENE=  }}  
{{STRUCTURE_1d32|  PDB=1d32  |  SCENE=  }}  


'''DRUG-INDUCED DNA REPAIR: X-RAY STRUCTURE OF A DNA-DITERCALINIUM COMPLEX'''
===DRUG-INDUCED DNA REPAIR: X-RAY STRUCTURE OF A DNA-DITERCALINIUM COMPLEX===




==Overview==
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Ditercalinium is a synthetic anticancer drug that binds to DNA by bis-intercalation and activates DNA repair processes. In prokaryotes, noncovalent DNA-ditercalinium complexes are incorrectly recognized by the uvrABC repair system as covalent lesions on DNA. In eukaryotes, mitochondrial DNA is degraded by excess and futile DNA repair. Using x-ray crystallography, we have determined, to 1.7 A resolution, the three-dimensional structure of a complex of ditercalinium bound to the double-stranded DNA fragment [d(CGCG)]2. The DNA in the complex with ditercalinium is kinked (by 15 degrees) and severely unwound (by 36 degrees) with exceptionally wide major and minor grooves. Recognition of the DNA-ditercalinium complex by uvrABC in prokaryotes, and by mitochondrial DNA repair systems in eukaryotes, might be related to drug-induced distortion of the DNA helix.
The line below this paragraph, {{ABSTRACT_PUBMED_2006181}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 2006181 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2006181}}


==About this Structure==
==About this Structure==
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[[Category: Double helix]]
[[Category: Double helix]]
[[Category: Right handed dna]]
[[Category: Right handed dna]]
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