1d3u: Difference between revisions

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[[Image:1d3u.gif|left|200px]]
{{Seed}}
[[Image:1d3u.png|left|200px]]


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{{STRUCTURE_1d3u|  PDB=1d3u  |  SCENE=  }}  
{{STRUCTURE_1d3u|  PDB=1d3u  |  SCENE=  }}  


'''TATA-BINDING PROTEIN/TRANSCRIPTION FACTOR (II)B/BRE+TATA-BOX COMPLEX FROM PYROCOCCUS WOESEI'''
===TATA-BINDING PROTEIN/TRANSCRIPTION FACTOR (II)B/BRE+TATA-BOX COMPLEX FROM PYROCOCCUS WOESEI===




==Overview==
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Recently the definition of the metazoan RNA polymerase II and archaeal core promoters has been expanded to include a region immediately upstream of the TATA box called the B recognition element (BRE), so named because eukaryal transcription factor TFIIB and its archaeal orthologue TFB interact with the element in a sequence-specific manner. Here we present the 2.4-A crystal structure of archaeal TBP and the C-terminal core of TFB (TFB(c)) in a complex with an extended TATA-box-containing promoter that provides a detailed picture of the stereospecific interactions between the BRE and a helix-turn-helix motif in the C-terminal cyclin repeat of TFB(c). This interaction is important in determining the level of basal transcription and explicitly defines the direction of transcription.
The line below this paragraph, {{ABSTRACT_PUBMED_10570130}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10570130 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10570130}}


==About this Structure==
==About this Structure==
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[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
[[Category: Transcription]]
[[Category: Transcription]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:25:18 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:20:24 2008''

Revision as of 19:20, 30 June 2008

File:1d3u.png

Template:STRUCTURE 1d3u

TATA-BINDING PROTEIN/TRANSCRIPTION FACTOR (II)B/BRE+TATA-BOX COMPLEX FROM PYROCOCCUS WOESEI

Template:ABSTRACT PUBMED 10570130

About this Structure

1D3U is a Protein complex structure of sequences from Pyrococcus woesei. Full crystallographic information is available from OCA.

Reference

The structural basis for the oriented assembly of a TBP/TFB/promoter complex., Littlefield O, Korkhin Y, Sigler PB, Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13668-73. PMID:10570130

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