1j1v: Difference between revisions

<table><tr><td colspan='2'>[[1j1v]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J1V FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j1v OCA], [https://pdbe.org/1j1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j1v RCSB], [https://www.ebi.ac.uk/pdbsum/1j1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j1v ProSAT], [https://www.topsan.org/Proteins/RSGI/1j1v TOPSAN]</span></td></tr>

[https://www.uniprot.org/uniprot/DNAA_ECOLI DNAA_ECOLI] Plays a key role in the initiation and regulation of chromosomal replication. Binds in an ATP-dependent fashion to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex exactly once per cell cycle. Binds the DnaA box (consensus sequence 5'-TTATC[CA]A[CA]A-3'); subsequent binding of DNA polymerase III subunits leads to replisome formation. The DnaA-ATP form converts to DnaA-ADP; once converted to ADP the protein cannot initiate replication, ensuring only 1 round of replication per cell cycle. DnaA can inhibit its own gene expression as well as that of other genes such as dam, rpoH, ftsA and mioC.<ref>PMID:9242693</ref> <ref>PMID:16077105</ref> <ref>PMID:17699754</ref>  Also required for replication of plasmid DNA; binds 4 dnaA boxes in the minimal plasmid RK2 replication origin (oriV).<ref>PMID:9242693</ref> <ref>PMID:16077105</ref> <ref>PMID:17699754</ref>  

[[Category: Escherichia coli]]

[[Category: Fujikawa N]]

[[Category: Katayama T]]

[[Category: Kurumizaka H]]

[[Category: Nureki O]]

[[Category: Shirouzu M]]

[[Category: Terada T]]

[[Category: Yokoyama S]]