1d5s: Difference between revisions

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[[Image:1d5s.gif|left|200px]]
{{Seed}}
[[Image:1d5s.png|left|200px]]


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{{STRUCTURE_1d5s|  PDB=1d5s  |  SCENE=  }}  
{{STRUCTURE_1d5s|  PDB=1d5s  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER'''
===CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER===




==Overview==
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Alpha1-antitrypsin deficiency, which can lead to both emphysema and liver disease, is a result of the accumulation of alpha1-antitrypsin polymers within the hepatocyte. A wealth of biochemical and biophysical data suggests that alpha1-antitrypsin polymers form via insertion of residues from the reactive center loop of one molecule into the beta-sheet of another. However, this long-standing hypothesis has not been confirmed by direct structural evidence. Here, we describe the first crystallographic evidence of a beta-strand linked polymer form of alpha1-antitrypsin: the crystal structure of a cleaved alpha1-antitrypsin polymer.
The line below this paragraph, {{ABSTRACT_PUBMED_10716194}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10716194 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10716194}}


==About this Structure==
==About this Structure==
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[[Category: Rcl cleavage]]
[[Category: Rcl cleavage]]
[[Category: Serpin fold]]
[[Category: Serpin fold]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:28:52 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:29:47 2008''
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