TRAIL

spinqualitylabelsall models Human TRAIL trimer residues 114-281 (grey, light green, yellow) complex with death receptor-5 extracellular domain (dark blue, dark green, olive), Zn+2 (grey) and Cl-1 (green) ions, 1d0g Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function TRAIL (TNF-related apoptosis-inducing ligand) or TNF ligand superfamily 10 functions as a ligand in the process of apoptosis. TRAIL binds to death receptors DR4, DR5, DcR1 and DcR2. For details see Molecular Playground/TRAIL. TRAIL-R2 is called DR5. TRAIL trimer residues complex with death receptor-5 extracellular domain (1d0g). Zn+2 and Cl-1 bind to 3 same Cys residues from different subunits of TRAIL trimer. Disease TRAIL concentrations are reduced in rheumatoid arthritis.

3D Structures of TRAIL

Updated on 07-December-2020

TRAIL-R2 domains – extracellular 54-184; transmembrane 208-242

Molecular Playground/TRAIL, 1d0g, 1du3, 5cir - hTRAIL 114-281 + TRAIL-R2 extracellular domain - human
4n90 - hTRAIL 114-281 + hTRAIL-R2 extracellular domain + antibody
1dg6 – hTRAIL jelly-roll domain 91-281
1d2q - hTRAIL 114-281
4i9x – hTRAIL-R2 extracellular domain + UL141
3x3f, 1za3, 4od2, 2h9g, 6t3j – hTRAIL-R2 extracellular domain + antibody
6nhw – hTRAIL-R2 transmembrane domain - NMR
6nhy – hTRAIL-R2 transmembrane domain (mutant) - NMR

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Michal Harel, Alexander Berchansky