1d8k: Difference between revisions

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[[Image:1d8k.gif|left|200px]]
{{Seed}}
[[Image:1d8k.png|left|200px]]


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{{STRUCTURE_1d8k|  PDB=1d8k  |  SCENE=  }}  
{{STRUCTURE_1d8k|  PDB=1d8k  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF THE CENTRAL CORE DOMAIN OF TFIIE BETA'''
===SOLUTION STRUCTURE OF THE CENTRAL CORE DOMAIN OF TFIIE BETA===




==Overview==
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Human general transcription factor TFIIE consists of two subunits, TFIIEalpha and TFIIEbeta. Recently, TFIIEbeta has been found to bind to the region where the promoter starts to open to be single-stranded upon transcription initiation by RNA polymerase II. Here, the central core domain of human TFIIEbeta (TFIIEbetac) has been identified by a limited proteolysis. This solution structure has been determined by NMR. It consists of three helices with a beta hairpin at the C-terminus, resembling the winged helix proteins. However, TFIIEbetac shows a novel double-stranded DNA-binding activity where the DNA-binding surface locates on the opposite side to the previously reported winged helix motif by forming a positively charged furrow. A model will be proposed that TFIIE stabilizes the preinitiation complex by binding not only to the general transcription factors together with RNA polymerase II but also to the promoter DNA, where double-stranded DNA starts to open to be single-stranded upon activation of the preinitiation complex.
The line below this paragraph, {{ABSTRACT_PUBMED_10716934}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10716934 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10716934}}


==About this Structure==
==About this Structure==
1D8K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D8K OCA].  
1D8K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D8K OCA].  


==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Winged helix-turn-helix]]
[[Category: Winged helix-turn-helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:34:27 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:40:31 2008''

Revision as of 19:40, 30 June 2008

File:1d8k.png

Template:STRUCTURE 1d8k

SOLUTION STRUCTURE OF THE CENTRAL CORE DOMAIN OF TFIIE BETA

Template:ABSTRACT PUBMED 10716934

About this Structure

1D8K is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of the central core domain of TFIIEbeta with a novel double-stranded DNA-binding surface., Okuda M, Watanabe Y, Okamura H, Hanaoka F, Ohkuma Y, Nishimura Y, EMBO J. 2000 Mar 15;19(6):1346-56. PMID:10716934

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