1d90: Difference between revisions

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[[Image:1d90.~~gif~~|left|200px]]

[[Image:1d90.png|left|200px]]

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~~'''~~REFINED CRYSTAL STRUCTURE OF AN OCTANUCLEOTIDE DUPLEX WITH I.T MISMATCHED BASE PAIRS~~'''~~

===REFINED CRYSTAL STRUCTURE OF AN OCTANUCLEOTIDE DUPLEX WITH I.T MISMATCHED BASE PAIRS===

~~==Overview==~~

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The ~~structure of~~ the ~~synthetic deoxyoctamer d~~(~~GGIGCTCC) has been determined by single crystal X-ray diffraction techniques to a resolution of 1~~.7A. ~~The sequence crystallises in space group P6(1~~), ~~with unit cell dimensions a = b = 45.07, c = 45.49A. The refinement converged with a crystallographic residual R = 0.14 and~~ the ~~location of 81 solvent molecules~~. ~~The octamer forms an A~~-~~DNA duplex with 6 Watson~~-Crick (G.C) base pairs and 2 inosine-thymine (I.T) pairs. Refinement of the structure shows it to be essentially isomorphous with that reported for d(GGGGCTCC) with the mispairs adopting a "wobble" conformation. Conformational parameters and base stacking interactions are compared to those for the native duplex d(GGGGCCCC) and other similar sequences. A rationale for the apparent increased crystal packing efficiency and lattice stability of the I.T octamer is given.

The line below this paragraph, {{ABSTRACT_PUBMED_2911488}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 2911488 is the PubMed ID number.

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==About this Structure==

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[[Category: Mismatched]]

[[Category: Modified]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 13~~:35:08 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:41:24 2008''

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-[[Image:1d90.gif|left|200px]]
+{{Seed}}
+[[Image:1d90.png|left|200px]]
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 {{STRUCTURE_1d90|  PDB=1d90  |  SCENE=  }}
-'''REFINED CRYSTAL STRUCTURE OF AN OCTANUCLEOTIDE DUPLEX WITH I.T MISMATCHED BASE PAIRS'''
+===REFINED CRYSTAL STRUCTURE OF AN OCTANUCLEOTIDE DUPLEX WITH I.T MISMATCHED BASE PAIRS===
-==Overview==
+<!--
-The structure of the synthetic deoxyoctamer d(GGIGCTCC) has been determined by single crystal X-ray diffraction techniques to a resolution of 1.7A. The sequence crystallises in space group P6(1), with unit cell dimensions a = b = 45.07, c = 45.49A. The refinement converged with a crystallographic residual R = 0.14 and the location of 81 solvent molecules. The octamer forms an A-DNA duplex with 6 Watson-Crick (G.C) base pairs and 2 inosine-thymine (I.T) pairs. Refinement of the structure shows it to be essentially isomorphous with that reported for d(GGGGCTCC) with the mispairs adopting a "wobble" conformation. Conformational parameters and base stacking interactions are compared to those for the native duplex d(GGGGCCCC) and other similar sequences. A rationale for the apparent increased crystal packing efficiency and lattice stability of the I.T octamer is given.
+The line below this paragraph, {{ABSTRACT_PUBMED_2911488}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 2911488 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_2911488}}
 ==About this Structure==
@@ Line 30: / Line 34: @@
 [[Category: Mismatched]]
 [[Category: Modified]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:35:08 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:41:24 2008''