1osg: Difference between revisions

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<StructureSection load='1osg' size='340' side='right'caption='[[1osg]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='1osg' size='340' side='right'caption='[[1osg]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1osg]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1OSG FirstGlance]. <br>
<table><tr><td colspan='2'>[[1osg]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OSG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mpv|1mpv]], [[1kxg|1kxg]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAFF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1osg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osg OCA], [https://pdbe.org/1osg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1osg RCSB], [https://www.ebi.ac.uk/pdbsum/1osg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1osg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1osg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osg OCA], [http://pdbe.org/1osg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1osg RCSB], [http://www.ebi.ac.uk/pdbsum/1osg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1osg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TN13B_HUMAN TN13B_HUMAN]] Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.<ref>PMID:10973284</ref>  Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity).<ref>PMID:10973284</ref>
[https://www.uniprot.org/uniprot/TN13B_HUMAN TN13B_HUMAN] Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.<ref>PMID:10973284</ref>  Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity).<ref>PMID:10973284</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cochran, A G]]
[[Category: Cochran AG]]
[[Category: Dixit, V M]]
[[Category: Dixit VM]]
[[Category: Fairbrother, W J]]
[[Category: Fairbrother WJ]]
[[Category: Gordon, N C]]
[[Category: Gordon NC]]
[[Category: Hymowitz, S G]]
[[Category: Hymowitz SG]]
[[Category: Kelley, R F]]
[[Category: Kelley RF]]
[[Category: Pan, B]]
[[Category: Pan B]]
[[Category: Starovasnik, M A]]
[[Category: Starovasnik MA]]
[[Category: Yan, M]]
[[Category: Yan M]]
[[Category: Yin, J P]]
[[Category: Yin JP]]
[[Category: Beta hairpin]]
[[Category: Immune system]]
[[Category: Jelly-roll]]
[[Category: Protein-peptide complex]]
Retrieved from "https://proteopedia.org/1osg"