1p7b: Difference between revisions

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<StructureSection load='1p7b' size='340' side='right'caption='[[1p7b]], [[Resolution|resolution]] 3.65&Aring;' scene=''>
<StructureSection load='1p7b' size='340' side='right'caption='[[1p7b]], [[Resolution|resolution]] 3.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1p7b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7B OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1P7B FirstGlance]. <br>
<table><tr><td colspan='2'>[[1p7b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P7B FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.65&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">chromosome 1 kirbac1.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 "Bacillus pseudomallei" Whitmore 1913])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1p7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7b OCA], [http://pdbe.org/1p7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p7b RCSB], [http://www.ebi.ac.uk/pdbsum/1p7b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1p7b ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7b OCA], [https://pdbe.org/1p7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p7b RCSB], [https://www.ebi.ac.uk/pdbsum/1p7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p7b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/P83698_BURPE P83698_BURPE]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p7b ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p7b ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The KirBac1.1 channel belongs to the inward-rectifier family of potassium channels. Here we report the structure of the entire prokaryotic Kir channel assembly, in the closed state, refined to a resolution of 3.65 angstroms. We identify the main activation gate and structural elements involved in gating. On the basis of structural evidence presented here, we suggest that gating involves coupling between the intracellular and membrane domains. This further suggests that initiation of gating by membrane or intracellular signals represents different entry points to a common mechanistic pathway.
Crystal structure of the potassium channel KirBac1.1 in the closed state.,Kuo A, Gulbis JM, Antcliff JF, Rahman T, Lowe ED, Zimmer J, Cuthbertson J, Ashcroft FM, Ezaki T, Doyle DA Science. 2003 Jun 20;300(5627):1922-6. Epub 2003 May 8. PMID:12738871<ref>PMID:12738871</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1p7b" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus pseudomallei whitmore 1913]]
[[Category: Burkholderia pseudomallei]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Antcliff, J F]]
[[Category: Antcliff JF]]
[[Category: Ashcroft, F M]]
[[Category: Ashcroft FM]]
[[Category: Cuthbertson, J]]
[[Category: Cuthbertson J]]
[[Category: Doyle, D A]]
[[Category: Doyle DA]]
[[Category: Ezaki, T]]
[[Category: Ezaki T]]
[[Category: Gulbis, J M]]
[[Category: Gulbis JM]]
[[Category: Kuo, A]]
[[Category: Kuo A]]
[[Category: Lowe, E D]]
[[Category: Lowe ED]]
[[Category: Rahman, T]]
[[Category: Rahman T]]
[[Category: Zimmer, J]]
[[Category: Zimmer J]]
[[Category: Cytosolic assembly]]
[[Category: Immunoglobulin fold]]
[[Category: Ion conduction]]
[[Category: Metal transport]]
[[Category: Transmembrane helice]]
Retrieved from "https://proteopedia.org/1p7b"