1dam: Difference between revisions

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[[Image:1dam.jpg|left|200px]]
{{Seed}}
[[Image:1dam.png|left|200px]]


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{{STRUCTURE_1dam|  PDB=1dam  |  SCENE=  }}  
{{STRUCTURE_1dam|  PDB=1dam  |  SCENE=  }}  


'''DETHIOBIOTIN SYNTHETASE COMPLEXED WITH DETHIOBIOTIN, ADP, INORGANIC PHOSPHATE AND MAGNESIUM'''
===DETHIOBIOTIN SYNTHETASE COMPLEXED WITH DETHIOBIOTIN, ADP, INORGANIC PHOSPHATE AND MAGNESIUM===




==Overview==
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The crystal structures of two complexes of dethiobiotin synthetase, enzyme-diaminopelargonic acid-MgADP-AlF3 and enzyme-dethiobiotin-MgADP-Pi, respectively, have been determined to 1.8 A resolution. In dethiobiotin synthetase, AlF3 together with carbamylated diaminopelargonic acid mimics the phosphorylated reaction intermediate rather than the transition state complex for phosphoryl transfer. Observed differences in the binding of substrate, diaminopelargonic acid, and the product, dethiobiotin, suggest considerable displacements of substrate atoms during the ring closure step of the catalytic reaction. In both complexes, two metal ions are observed at the active site, providing evidence for a two-metal mechanism for this enzyme.
The line below this paragraph, {{ABSTRACT_PUBMED_9865950}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9865950 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9865950}}


==About this Structure==
==About this Structure==
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[[Category: Magnesium]]
[[Category: Magnesium]]
[[Category: Phosphoryl transfer]]
[[Category: Phosphoryl transfer]]
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